Two recent prospective studies exploring mechanisms of type 2 diabetes remission have demonstrated that early improvements of insulin sensitivity and intracellular glucose disposition were secondary to caloric restriction shortly after surgery and from the amount of weight lost over time.[31, 32] This suggests that the predominant effect of bariatric surgery on type 2 diabetes is due to weight loss, despite changes in gut hormones. The gene discussed is INS; the disease is type 2 diabetes mellitus.