In a previous study, NM significantly (P<0.05) reduced bFGF-induced angiogenesis [utilizing a chorioallantoic membrane (CAM) assay] in chick embryos, as well as decreased human osteosarcoma U2OS cell expression of VEGF, angiopoietin-2, bFGF, PDGF and TGFβ-1 (7). Here, ANGPT2 is linked to osteosarcoma.