For those patients treated with surgery alone, an independent influence on cancer-progression was detected for the TYMS mRNA expression (p = 0.04; Table 4), while for those patients submitted to adjuvant 5-FU treatment after surgery, the MMR and the CIMP were the most important predictors of survival (p = 0.04 and p = 0.05 respectively; Table 4). The gene discussed is TYMS; the disease is cancer.