CD44 and neuroblastoma: A study by Valentiner et al. reported that expression of CD44 was associated with a metastatic pattern of the neuroblastoma cell lines engrafted in the SCID mice and that CD44-negative neuroblastomas developed numerous micrometastases in the lung interstitium while CD44-positive neuroblastomas produced multicellular metastases predominantly located in the intra- and periarterial space of the lung[44].