Medical care in the absence of adequate self-care is rarely effective for chronic illnesses (Bonsignore & Suhl, 2006), and DM is a complex disease to manage, and most of the care involving self-management (Chlebowy, Hood & LaJoie, 2010), so people with diabetes must be equipped with the information necessary to implement the routine and complicated adequate self-care (Chen et al., 2009), these information include educating about home blood glucose monitoring, meal planning, and recognizing how and when to administer insulin or take oral diabetes medications (Bonsignore & Suhl, 2006). This evidence concerns the gene INS and diabetes mellitus.