By contrast, the MTHFR polymorphism A1298C was not associated with cervical disease development (normal/cervical lesions and tumours: wild homozygote 30/51 (0.60/0.51), heterozygote 19/44 (0.38/0.44), mutant homozygote 1/5 (0.02/0.05); OR = 1.441, P = 0.2278). Here, MTHFR is linked to neoplasm.