This study aimed to investigate MTHFR polymorphisms and the methylation pattern of MTHFR promoter in relationship with susceptibility to cervical lesions and cervix papillomaviruses infection in Romania, which has one of the highest rates of cervical cancer in Europe (incidence 33.9/100,000; mortality 16.9/100,000 – Romanian Statistic Annual 2004). This evidence concerns the gene MTHFR and cervical cancer.