When ICLs are encountered by the replication fork a Fanconi anemia (FA) protein complex comprised of FANCA, -B, -C, -E, -F, -G, -L, and -M mono-ubiquitylates FANCD2 that interacts with DSB repair proteins including the breast cancer susceptibility gene BRCA1, FANCD1/BRCA2, FANCJ, and the MRN complex (Kee and D’Andrea, 2010). The gene discussed is BRCA1; the disease is breast cancer.