So called laminopathies such as Hutchinson–Gilford-progeria-syndrome (HGPS), atypical WS, restrictive dermopathy (RD), and mandibuloacral dysplasia (MAD) are caused by mutations in lamin A and the ZMPSTE24 farnesyltransferase required for lamin A processing (Ramirez et al., 2007). Here, ZMPSTE24 is linked to mandibuloacral dysplasia.