Consistent with the finding that the overexpression of some of the EYA isoforms correlates with tumor growth and increased metastasis in various cancers [25–27], it has been reported that the Tyr phosphatase activity of EYA promotes tumor cell migration, invasion and transformation, concomitant with alterations in the actin cytoskeleton and activation of Rac and Cdc24, which are members of the Rho-GTPase family that play important and diverse roles in the reorganization of the actin cytoskeleton [28]. Here, AKT1 is linked to neoplasm.