This genetic model of hypertension exhibits enhanced NAD(P)H oxidase-mediated O2 generation in resistance arteries (mesenteric), conduit vessels (aorta), and kidneys [26] 8-Hydroxy-2′-deoxyguanosine, a marker for oxidative stress-induced DNA damage, and protein carbonylation, a marker for oxidation status of proteins, are overexpressed in the aorta, heart, and kidney of SHR compared to their normotensive cohorts [26]. This evidence concerns the gene FMO5 and Hypertension.