To determine the significance of these polymorphisms, we focused on OGG1 Ser326Cys (rs1052133), MUTYH Gln324His (rs3219489), APEX1 Asp148Glu (rs1130409), XRCC1 Arg399Gln (rs25487), and XRCC3 Thr241Met (rs861539) and examined the relationship between the different genotypes and the survival of Japanese lung cancer patients. Here, XRCC3 is linked to lung cancer.