In this study, we assessed the OGG1 Ser326Cys, MUTYH Gln324His, APEX1 Asp148Glu, XRCC1 Arg399Gln, and XRCC3 Thr241Met gene polymorphisms that may influence DNA repair capacity and their association with the overall survival of lung cancer patients. The gene discussed is APEX1; the disease is lung cancer.