MYCN and neuroblastoma: Notably, MYCN has been recently discovered to bind and transcriptionally downregulate another epigenetically controlled miRNA, miR-335, which in turn regulates genes in the TGF-β non-canonical pathway, such as the Rho-associated coiled-coil containing protein (ROCK1), MAPK1 and putative member LRG1, leading to inhibition of invasiveness and migratory potential of NB cells [117].