On the other hand, vascular endothelial growth factor (VEGF), an important predictive factor for various malignancies including CRC, was also found to increase brain microvascular endothelial cell (BMEC) monolayer permeability by modulating transendothelial migration [63], reducing occludin expression and disrupting ZO-1 and occludin organization, and to lead to tight junction disassembly [64,65]. Here, OCLN is linked to colorectal carcinoma.