The latter is particularly pertinent as the standardised assessment of self-care (i.e. using a questionnaire measure) does not fit easily with a condition such as diabetes, in which each individual is likely to have a different treatment regimen prescribed or is encouraged to take an active role in regulating his/her treatment, adopting a flexible approach (e.g. self-titration rather than fixed insulin doses and mealtimes). This evidence concerns the gene INS and diabetes mellitus.