On the whole, the work presented herein establishes that not only in HCC there is a correlation between the selenium availability, and the cellular amount of two proteins, GPX1 and SELK, but also that sodium selenite shows an anti-inflammatory effect and might, therefore, inhibit the tumor invasiveness promoting a cellular regression also because is adequately related to the specific functional paths. This evidence concerns the gene GPX1 and hepatocellular carcinoma.