We have also reported that miR-375 is the most down-regulated miRNA, and that its ectopic expression is able to induce apoptosis of gastric carcinoma cells through downregulation of PDK1 and 14-3-3zeta [6], implying a tumor-suppressive role of miR-375 in gastric carcinoma cells. Here, PDK1 is linked to gastric carcinoma.