For MMP8, the AUC on ROC analysis for patients with AAD was 0.75 (95% CI, 0.66 to 0.84) versus all controls, 0.75 (95% CI, 0.59 to 0.91) versus aortic aneurysm without dissection, 0.67 (95% CI, 0.42 to 0.91) versus inflammatory disease, 0.82 (95% CI, 0.69 to 0.95) versus acute coronary syndrome, 0.66 (95% CI, 0.44 to 0.88) versus other diagnoses and 0.82 (95% CI, 0.73 to 0.91) versus uncertain diagnoses. The gene discussed is MMP8; the disease is aortic aneurysm.