NLRP3 and cryopyrin-associated periodic syndrome: Familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS) and chronic infantile neurological cutaneous and articular syndrome (CINCA) represent the clinical spectrum associated to mutations in NLRP3 gene coding for the cryopyrin protein [1,2] and are collectively known as cryopyrin-associated periodic syndrome (CAPS).