In this report, we describe the differential expression of Fz1 in the colon cancer TME and provide evidence of autocrine regulation in tumor cells and paracrine regulation by factors within the TME on Fz1 expression in non-malignant mucosal epithelium, as well as lack of paracrine regulation in proximity to pre-malignant colon adenomas. This evidence concerns the gene FZD1 and malignant colon neoplasm.