However, Fz1 mRNA was markedly increased in villous adenomas in comparison to normal mucosa and tubular adenomas (p=0.0176 1 way ANOVA, p<0.05 Newman-Kuels for both comparisons; p=0.024 villous vs. tubular by unpaired t-test; p=0.012 villous vs. normal by unpaired t-test). Here, FZD1 is linked to villous adenoma.