Villous adenomas have a substantially higher malignant potential than tubular adenomas.At the protein level, villous adenomas had abundant Fz1 expression (Figure 3, panels G and H) but no expression was detected in normal mucosa or tubular adenomas, suggesting that the molecular switch or conditions within the tumor microenvironment permissive for Fz1 expression occur in the transition from tubular to villous histologies.. This evidence concerns the gene FZD1 and neoplasm.