Also, vitamin A and Zinc supplementation on serum fasting blood sugar, insulin, apoprotein B and A-1 in patients with type I diabetes has been carried out [21], and found that combined zinc and vitamin A supplementation can improve serum apoprotein A-I, apoprotein B and the apoprotein B/apoprotein A-I ratio in patients with type I diabetes. The gene discussed is INS; the disease is type 1 diabetes mellitus.