In agreement with previous reports [12,21], both Vpx-VLPs and exogenous dN increased HIV-1 infectivity in PMA-THP-1 cells in the absence of IFNα (~2-fold; Figure 3A), but had no significant effect on HIV-1 infection of dividing THP-1 cells (Figure 3B). The gene discussed is IFNA1; the disease is HIV-1 infection.