In keeping with observations made in dividing THP-1 cells, this further demonstrates that SAMHD1 degradation does not necessarily correlate with a rescue of HIV-1 infection, and suggests that factors distinct from SAMHD1 are involved in the IFNα-induced block to HIV-1 infection in dividing U87-MG and THP-1 cells. Here, SAMHD1 is linked to HIV-1 infection.