Of particular interest, Tm3 (92.4-118.3 Mbp, chromosome 3) demonstrated complete overlap with a susceptibility locus identified in three unrelated murine models of spontaneous experimental colitis: G-protein alpha inhibitory 2 chain knock-out (Gnai2-/-) mice (Gpdc1 locus)[11]; C3H/HeJBir IL10-deficient mice (Cdcs1 locus)[12]; T-bet-/-Rag2-/- double-deficient mice that resemble ulcerative colitis (TRUC) (Cdcs1 locus)[13]. This evidence concerns the gene GNAI2 and colitis.