Nevertheless, the coordinated expression of ECM3 genes in breast carcinomas, confirmed by the good performance of the average expression profile of 4 genes (COL1A1, COL5A2, SPARC and LAMA4) in discriminating ECM3 tumors and evaluating their prognosis, argues for their active involvement in the behavior of breast carcinomas. The gene discussed is SPARC; the disease is breast carcinoma.