Moreover, the average expression of the gene set COL1A1, COL5A2, SPARC and LAMA4, with AUC greater than the 75th percentile of the randomly selected 4-gene AUCs in almost all datasets, was significantly higher in tumor specimens classified in microarray analysis of ITA dataset [13] as ECM3 in comparison with non-ECM3 tumors when tested by qPCR using RNA from FFPE sections (p = 0.005, Figure 2A). This evidence concerns the gene SPARC and neoplasm.