In vitro effective doses of the potent PMC analog PMC-A (25–100 μM) caused cell death in a dose-dependent manner among all three HCT116 colon cancer cell lines (wt, p53−/−, and Bax −/−) as indicated by increased Annexin-V affinities in cell populations (Fig. 4A). The gene discussed is ANXA5; the disease is colonic neoplasm.