Among the transcription factors, NF-κB, SP1, p53 and AP-2 (activating protein-2) which all were previously shown to be activated by p38 kinase activity in various cellular scenarios were implicated in direct transcriptional regulation of Bcl-2 in stressed cancer cells [17], [54], [55], [60], [64]–[67]. Here, BCL2 is linked to cancer.