In cardiac disease, functional assessment of miR-21 implicates PDCD4 [41], [48], [52], [53], SPRY1 [22] or SPRY2 [54], Phosphatase and tensin homolog [23], [29], [55], and Fas ligand [55] as the major targets of miR-21. The gene discussed is PTEN; the disease is heart disorder.