SPP1 and neoplasm: Previously, it has been reported that cells change their cell-cell adhesion properties, rearrange their extracellular matrix (ECM) environment, and reorganize their cytoskeletons to facilitate migration and invasion.A lot of evidences have indicated that osteopontin facilitated the attachment of cells to the ECM through binding to several types of integrins (INTs), enhanced the expression and activity of MMP-2, and promoted tumor growth and metastasis through the activation of survival pathways [9]–[13].