Autoantibodies against NCL and Ku70/Ku80 are characteristic features of SLE [37], [38] and release of free DNA from EMSA-bound DNA in vitro implies that autoantibodies in vivo could impair the function of these proteins by disrupting the binding of bound proteins from target DNA, including the rs13023380 locus. Here, XRCC6 is linked to systemic lupus erythematosus.