Four different changes in the FZD4 gene, viz., p.K203N, p.I256V, p.A370G, and p.R466W, were uniquely found in patients with advanced ROP [15,36], while two mutations in the NDP gene, viz., p.L108P and p.R121W [9], and one compound mutation in the FZD4 gene, viz., p.P33S/p.P168S [15,37], were found either in patients with advanced ROP (Table 2) or FEVR. This evidence concerns the gene NDP and retinopathy of prematurity.