MiR-146a regulates extracellular matrix protein in retinal microvessels, miR-146a is involved retinal neovascularization, and the upregulation of miR-146a induces the overexpression of VEGF: interestingly, VEGF is elevated in ocular fluids of eyes with uveal melanoma [44-47]. The gene discussed is VEGFA; the disease is uveal melanoma.