Both types of BPES are caused by mutation of the FOXL2 gene [3,4], located at 3q23, which encodes a forkhead transcription factor containing a 100 amino acid DNA-binding forkhead domain and a polyalanine domain of 14 alanines. The gene discussed is FOXL2; the disease is blepharophimosis, ptosis, and epicanthus inversus syndrome.