FTLD-TDP (Figures 2E–G) can be subdivided into four subtypes (A–D) based on the morphology and distribution of lesions (Mackenzie et al., 2011) and can also be associated with TDP-43 inclusions in the anterior horn of the spinal cord and gliosis of the corticospinal tracts, suggesting a continuum of FTLD with amyotrophic lateral sclerosis (ALS; FTLD-ALS) (Geser et al., 2008, 2009). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.