TARDBP and amyotrophic lateral sclerosis: Extrapyramidal symptoms may predict a tauopathy (Forman et al., 2006; Josephs et al., 2006b) while co-morbid ALS is almost certainly due to TDP-43 aggregation (Shi et al., 2005; Forman et al., 2006; Josephs et al., 2006b).