Although cultured neurons from PINK1 mutant animals and/or cell lines in which PINK1 expression is manipu- latedbecome vulnerable to several insults, animal models thatcarry a PINK1 mutation do not develop PD-like symptoms, such as degeneration of dopaminergic neurons, motor deficits, and Lewy body formation (Deng et al., 2005; Haque et al., 2008). Here, PINK1 is linked to Parkinson disease.