The aim of the present study was to elucidate the mechanisms of the in vitro anti-inflammatory and anti-allergic activities of PHF, Danpi and GA via their modulation of: (i) expression of cell surface adhesion molecules and (ii) the release of chemokines and cytokines from allergy-related alarmin IL-33-activated human basophils, which are crucial effector cells of allergic inflammation in allergic asthma and AD [27]. This evidence concerns the gene IL33 and Alzheimer disease.