Since the immunopathological mechanism of allergic diseases such as AD is complex, involving both cellular and humoral components of the immune system [47], the above results suggest that TCM Pentaherb Formula and its herbal component Danpi and bioactive compound gallic acid can suppress inflammation elicited by IL-33-activated allergic inflammation-related effector cells, namely, the basophils, by the inhibition of the expression of adhesion molecules and allergy-related cytokines and chemokine. Here, IL33 is linked to allergic disease.