Cell-based flavivirus immunodetection (CFI), which measures viral protein expression after infection by ELISA, and luciferase reporter viral replicon assay were used to identify inhibitors of viral RNA synthesis namely, the adenosine nucleoside inhibitor NITD008 [14], NS4B inhibitor NITD-618 [46] and NITD-982, an inhibitor of host dihydroorotate dehydrogenase (DHODH) [47]. The gene discussed is DHODH; the disease is infection.