Thus, as a result of their highly expressed TH2 promoting and TH1 inhibiting CPBs infection of MKP-2−/− mice with L. mexicana, unlike infection with L. major, is able to rescue and promote the TH2 component of the parasite specific T cell response which is less subject to Arginase-1 induced hypo-responsiveness than TH1 responses [27]. Here, DUSP4 is linked to infection.