BIRC2 and neoplasm: It is thought that this induced resistance in a wide variety of tumor cells occurs via induction of NF-κB effector genes, including Bcl-2 [45], Bcl-xL [46], survivin [47], XIAP [48], c-IAP1 [49] and c-IAP2 [49] that are known to mediate protective responses to chemotherapeutic agents and radiation.