As shown in Figure 6, Western blot analysis of lysates from six independent tumor samples indicated that while both markers of proliferation (PCNA and Ki-67) decreased in response to α-tomatine treatment (Figure 6A and B), levels of both markers of apoptosis (cleaved-PARP and caspase-3) increased (Figure 6C and D). This evidence concerns the gene CASP3 and neoplasm.