Although the precise mechanism(s) for the altered metabolism in cancers is unknown, previous studies have demonstrated diverse mechanisms, including oncogene activation, tumour suppressor gene inactivation, hypoxia, up-regulation of the LDH-A subunit, and absent or decreased expression of the LDH-B subunit [5], [14], [15], [16], [19]. The gene discussed is LDHB; the disease is neoplasm.