Recent evidence suggests that abnormal mTOR pathway activity is critical for epileptogenesis in TSC and that mTORC1 inhibitors, such as rapamycin, may be particularly effective therapies for epilepsy, not just as an anticonvulsant to treat seizures, but also as antiepileptogenic therapy to prevent epilepsy in TSC [16], [17]. The gene discussed is MTOR; the disease is epilepsy.