Here, we demonstrate that treatment of PANC-1 or MiaPaCa-2 pancreatic cancer cells with either rapamycin or active-site mTOR inhibitors suppressed S6K and S6 phosphorylation induced by insulin, a combination of insulin and the GPCR agonist neurotensin or serum. The gene discussed is RPS6KB1; the disease is familial pancreatic carcinoma.