CD4 and acute respiratory distress syndrome: In regards to phenotype, a significant decrease in the number of PMNs (GR1+) and CD4+ cells on day 5 and CD19+ B cells on day 9 was observed in curcumin-treated reovirus 1/L-ALI/ARDS mice versus untreated reovirus 1/L-ALI/ARDS mice (Fig. 6A and B).