We demonstrate from the inflammatory infiltrate an early (day 5) and significant rise in IL-6, G/M-CSF, and MCP-1 in curcumin-treated reovirus 1/L-ALI/ARDS which is not mirrored by untreated reovirus 1/L-ALI/ARDS until day 9. The gene discussed is CCL2; the disease is acute respiratory distress syndrome.