ACTA1 and acute respiratory distress syndrome: To provide further evidence for the anti-fibrogenic action of curcumin in reovirus 1/L-ALI/ARDS, we analyzed pulmonary expression of TN-C, an extracellular matrix glycoprotein that is highly expressed in adult lung parenchyma following acute lung injury [37]–[40] and pulmonary levels of α-SMA and E-cadherin, two well-established markers of epithelial to mesenchymal transition (Fig. 4).