NFKB1 and acute respiratory distress syndrome: However, although NFκB plays a major role in regulating expression of cytokines/chemokines, the effects of curcumin in reovirus 1/L-ALI/ARDS cannot solely be attributed to its effect on NFκB since glucocorticoids also inhibit NFκB but do not suppress the development, progression, and mortality associated with reovirus1/L-ALI/ARDS [7], [8].