While curcumin down regulates the expression IL-6, IL-10, IFNγ and MCP-1 in curcumin-treated reovirus 1/L-ALI/ARDS on day 14, untreated reovirus 1/L-ALI/ARDS express high levels of these cytokines/chemokines especially, IFNγ and MCP-1. The gene discussed is IFNG; the disease is acute respiratory distress syndrome.