Random-effects model of meta-analysis shows significant associations of polymorphisms of GSTM1 null gene (OR = 1.47, 95% CI: 1.21 to 1.79, P<0.001), GSTT1 null gene (OR = 1.38, 95% CI: 1.14 to 1.65, P<0.001), and GSTM1-GSTT1 dual null gene (OR = 1.79, 95% CI: 1.26 to 2.53, P<0.001), respectively, with HCC risk in the Chinese population. Here, GSTM1 is linked to hepatocellular carcinoma.