Sixteen out of 18 genes (89%) which correlated significantly with meTIMP and/or 6-TGN or the meTIMP/6-TGN concentration ratio in the expanded patient cohort (n = 54) interacted in networks with 41 genes present at 6, 4 or 21 susceptibility loci identified for CD, UC or IBD [42], respectively, as judged by the STRING analysis (Figure 3; FAM156A and HVCN1 were not present in any network). Here, FAM156A is linked to inflammatory bowel disease.