NFKB1 and pancreatic insulinoma: Transfection of an NF-κB “superrepressor” gene into MIN-6 insulinoma cell lines, human CM and NES2Y β cell lines, INS-1E cells, purified rat islet β cells, and human and mouse islets led to their protection from cytokine-induced, NF-κB-mediated apoptosis in vitro[32], [39], [40].