Trying to generalize miR-126&126* function, as recipients of miR transduction we selected two metastatic melanoma cell lines characterized by a different mutational status of BRAF and NRAS (i.e. BRAF V600E and NRAS wt for A375M and BRAF wt and NRAS Q61R for Me665/1) [33], [34]. This evidence concerns the gene NRAS and melanoma.