Overall, a significantly increased risk of cancer was is associated with the PAI-1 4G polymorphism for the allele contrast (4G vs. 5G: OR = 1.10, CI = 1.03–1.18, I2 = 49.5%), the additive genetic model (4G/4G vs. 5G/5G: OR = 1.21 CI = 1.06–1.39, (Fig. 2); 4G/4G vs. 4G/5G: OR = 1.10 CI = 1.03–1.18), the recessive genetic model (4G/4G vs. 4G/5G+5G/5G OR = 1.11 CI = 1.04–1.18). The gene discussed is SERPINE1; the disease is cancer.