To determine whether the recognition of cancer cells by SATB1565–574-specific CD8+ T cells was HLA-I restricted, we co-cultured SATB1565–574 -specific T cells with either Skov-1 or Jeko-1 cells in the presence of either anti-HLA-I mAb (W6/32) or anti-HLA-II mAb. The gene discussed is CD8A; the disease is cancer.