SATB1 promotes tumor growth and metastasis by reprogramming chromatin organization and transcription profiles, and is highly expressed in a variety of cancers including breast cancer [18], laryngeal squamous cell carcinoma [19], endometrioid endometrial cancer [20], hepatocellular carcinoma [21], rectal cancer [22], cutaneous malignant melanoma [23], gastric cancer [24], [25], ovarian cancer [26], prostate cancer [27], lung cancer [28] and glioma [29]. This evidence concerns the gene SATB1 and rectal cancer.