Similarly, Sathya et al [40] showed that the regulation of AR transcriptional activity and the role of AR in proliferation are mechanistically distinct; they developed tissue-specific AR modulators (SARMs) that are very weak as activators of AR transcriptional activity but are as effective as dihydrotestosterone (DHT) in stimulating the proliferation of prostate cancer cells. The gene discussed is AR; the disease is Familial prostate cancer.