HIF1A and neoplasm: CAM assay was performed and showed that miR-199a or miR-125b alone was sufficient to inhibit A2780 cell-induced angiogenesis, whereas HIF-1α overexpression restored miR-199a- and miR-125b-inhibited angiogenesis (Figure 5G), suggesting that inhibitory effects of miR-199a- and miR-125b on tumor-induced angiogenesis are mediated by HIF-1α downregulation.