CD4 and autoimmune disease: We detected NR4A2 upregulation amongst T cells during the development of EAE and EAU, a Th1/Th17-mediated autoimmune disease of the retina: T cell expression of NR4A2 was observed from the earliest stages of both EAE and EAU in CD4+ T cell infiltrates in the target organ and, as well as a later NR4A2 upregulation amongst circulating blood CD4+ T cells (Fig. 1A&B) after the peak of clinical disease (Fig. S1A&B).