Previous studies supported a significant link of the PI3K/Akt, Jak/Stat, FAK, TGFβ/Smad and MAPKs (e.g., JNK, ERK1/2 and p38) with cancer cells proliferation, invasion, and metastasis for a wide range of tumors [11], [63], [64]. The gene discussed is TGFB1; the disease is cancer.