However, in response to LR17938, the level of CD4+Foxp3+ Tregs and double positive CD4+CD8+Foxp3+ Tregs returned to normal in the ileum of rats with NEC (compared to untreated NEC animals, p<0.05 and p<0.01, respectively) (Figure 3e and 3f). Here, CD4 is linked to necrotizing enterocolitis.