However, LR17938 significantly decreased the percentage of double CD4+CD8+Foxp3+ T cells in the MLN compared to NEC rats without probiotic (20.6±0.7 in NEC+LR17938-fed vs. 24.5±1.8 in NEC, p<0.05) (Figure 4d). This evidence concerns the gene CD4 and necrotizing enterocolitis.